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P63
From Proteopedia
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| - | <StructureSection load='' size=' | + | <StructureSection load='' size='350' side='right' caption='P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code [[3us0]])' scene='70/706258/Cv/1'> |
== Function == | == Function == | ||
| Line 10: | Line 10: | ||
== Relevance == | == Relevance == | ||
| - | One isoform of p63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. | + | One isoform of p63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. Another isoform functions in apoptosis<ref>PMID:16998800</ref>. |
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='70/706258/Cv/ | + | *<scene name='70/706258/Cv/8'>A-B dimer interactions with DNA</scene>. Water molecules are shown as red spheres. |
*<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>. | *<scene name='70/706258/Cv/5'>C-D dimer interactions with DNA</scene>. | ||
| - | *<scene name='70/706258/Cv/ | + | *<scene name='70/706258/Cv/7'>Zn coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of P63 == | == 3D Structures of P63 == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *p63 DBD | + | *p63 DBD (153-384) |
**[[2rmn]] – hP63 - human - NMR<br /> | **[[2rmn]] – hP63 - human - NMR<br /> | ||
**[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | **[[3qym]], [[3qyn]], [[3us0]], [[3us1]], [[3us2]] – hP63 + DNA<br /> | ||
| + | **[[7z71]], [[7z7e]] – hP63 + darpin<br /> | ||
| - | *p63 tetramerization domain | + | *p63 tetramerization domain (397-455) |
**[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | **[[3zy0]], [[3zy1]], [[4a9z]] – hP63 <br /> | ||
| + | **[[2nb1]] – hP63 + p73 tetramerization domain - NMR<br /> | ||
| + | **[[7z73]] – hP63 + darpin<br /> | ||
| - | *p63 C terminal domain | + | *p63 C terminal domain (501-575) |
**[[1rg6]] – hP63 - NMR<br /> | **[[1rg6]] – hP63 - NMR<br /> | ||
| - | *p63 SAM domain | + | *p63 SAM domain (543-622) |
**[[2y9t]] – hP63 - NMR<br /> | **[[2y9t]] – hP63 - NMR<br /> | ||
**[[2y9u]] – hP63 (mutant)<br /> | **[[2y9u]] – hP63 (mutant)<br /> | ||
| + | **[[7z72]] – hP63 + darpin<br /> | ||
| + | **[[5n2o]] – P63 (mutant) - mouse<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of P63
Updated on 21-August-2023
References
- ↑ Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:http://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
- ↑ Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
- ↑ Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
- ↑ Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:http://dx.doi.org/10.4161/cc.6.3.3792
- ↑ Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:http://dx.doi.org/10.1002/jcp.20829
