Neurophysin

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<StructureSection load='' size='450' side='right' caption='Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code [[1npo]])' scene='70/706270/Cv/1' pspeed='8'>
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<StructureSection load='' size='350' side='right' caption='Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code [[1npo]])' scene='70/706270/Cv/1' pspeed='8'>
== Function ==
== Function ==
'''Neurophysins''' are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland<ref>PMID:3147712</ref>.
'''Neurophysins''' are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland<ref>PMID:3147712</ref>.
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== Structural highlights ==
== Structural highlights ==
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<scene name='70/706270/Cv/3'>Neurophysin-2/oxytocin interactions</scene>.
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<scene name='70/706270/Cv/4'>Neurophysin-2/oxytocin interactions</scene>.
</StructureSection>
</StructureSection>

Current revision

Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code 1npo)

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3D Structures of neurophysin

Updated on 23-July-2019

References

  1. Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID:3147712
  2. Nagasaki H, Ito M, Yuasa H, Saito H, Fukase M, Hamada K, Ishikawa E, Katakami H, Oiso Y. Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. J Clin Endocrinol Metab. 1995 Apr;80(4):1352-6. PMID:7714110 doi:http://dx.doi.org/10.1210/jcem.80.4.7714110

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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