Phosphomannomutase

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<StructureSection load='' size='450' side='right' caption='Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry [[2fue]])' scene='48/481638/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry [[2fue]])' scene='48/481638/Cv/1'>
== Function ==
== Function ==
'''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism.
'''Phosphomannomutase''' (PMM) catalyzes the conversion of α-D-mannose 1-phosphate to D-mannose 6-phosphate. PMM participates in fructose and mannose metabolism.
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== Structural highlights ==
== Structural highlights ==
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The PMM structure contains a <scene name='48/481638/Cv/6'>core domain and a cap domain</scene>. It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The <scene name='48/481638/Cv/4'>active site of PMM is located at the interface of the core and cap domains of the molecule</scene><ref>PMID:16540464</ref>. Water molecules shown as red spheres.
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The PMM structure contains a <scene name='48/481638/Cv/7'>core domain and a cap domain</scene>. It is known that in order for the substrate to bind, the cap must dissociate from the core domain and then re-associate to seal the active site from solvent molecules. The <scene name='48/481638/Cv/8'>active site of PMM is located at the interface of the core and cap domains of the molecule</scene><ref>PMID:16540464</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
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*Phosphomannomutase
*Phosphomannomutase
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**[[1k2y]] – PaPMM (mutant) – ''Pseudomonas aeruginosa''<br />
 
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**[[1k35]] – PaPMM<br />
 
**[[2amy]], [[2q4r]] – hPMM2 – human<br />
**[[2amy]], [[2q4r]] – hPMM2 – human<br />
**[[2fuc]] – hPMM1 + Mg<br />
**[[2fuc]] – hPMM1 + Mg<br />
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**[[6cfr]], [[6cfs]], [[6cft]], [[6cfu]] – hPMM1 (mutant) + Mg<br />
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**[[6cfv]] – hPMM1 + Mg + inosine<br />
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**[[2fue]] – hPMM1 + α-D-mannose-1-phosphate + Mg<br />
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**[[7o0c]] – hPMM2 + Mg<br />
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**[[7o5z]] – hPMM2 (mutant) + Mg<br />
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**[[7o1b]], [[7o4g]], [[7o58]] – hPMM2 + α-D-glucose-1,6-bisphosphate + Mg<br />
**[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br />
**[[2i54]] – LmPMM + Mg – ''Leishmania Mexicana''<br />
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**[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br />
 
**[[2i55]] - LmPMM + α-D-glucose-1,6-bisphosphate + Mg<br />
**[[2i55]] - LmPMM + α-D-glucose-1,6-bisphosphate + Mg<br />
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**[[2fue]] – hPMM1 + α-D-mannose-1-phosphate + Mg<br />
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**[[3f9r]] - PMM + Mg – ''Trypanosoma brucei''<br />
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**[[8b5v]] - PMM + Mg – ''Trypanosoma cruzi''<br />
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**[[6i5x]] – PMM + Mg – ''Aspergillus fumigata''<br />
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**[[1k35]] – PaPMM – ''Pseudomonas aeruginosa''<br />
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**[[1k2y]] – PaPMM (mutant)<br />
**[[1p5d]], [[1p5g]] – PaPMM + α-D-glucose-1-phosphate<br />
**[[1p5d]], [[1p5g]] – PaPMM + α-D-glucose-1-phosphate<br />
**[[4hjh]] - PaPMM + D-glucose-6-phosphate<br />
**[[4hjh]] - PaPMM + D-glucose-6-phosphate<br />
**[[1pcj]], [[1pcm]] - PaPMM + α-D-mannose-1-phosphate<br />
**[[1pcj]], [[1pcm]] - PaPMM + α-D-mannose-1-phosphate<br />
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**[[5ue7]] - PMM – ''Candida albicans''<br />
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**[[7myv]] – PMM + Mg – ''Plasmodium falciparum''<br />
*Phosphomannomutase/Phosphoglucomutase complex
*Phosphomannomutase/Phosphoglucomutase complex
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**[[2h5a]] - PaPMM/PGM + xylose-1-phosphate<br />
**[[2h5a]] - PaPMM/PGM + xylose-1-phosphate<br />
**[[2f7l]] - PMM/PGM – ''Sulfolobus tokodaii''<br />
**[[2f7l]] - PMM/PGM – ''Sulfolobus tokodaii''<br />
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**[[3uw2]] – PMM/PGM PGM domain + phosphate – ''Burkholderia thailandensis''
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**[[3uw2]] – PMM/PGM PGM domain + phosphate – ''Burkholderia thailandensis''<br />
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**[[6mnv]] – XcPMM/PGM + Mg + CH2FG1P – ''Xanthomonas citri''<br />
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**[[6n1e]] – XcPMM/PGM + Mg + methyl-glucose-6-phosphate <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human phosphomannomutase 1 complex with α-D-mannose-1-phosphate and Mg+2 ion (green) (PDB entry 2fue)

Drag the structure with the mouse to rotate

3D Structures of phosphomannomutase

Updated on 28-August-2023

References

  1. ↑ Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E. Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet. 1997 May;16(1):88-92. PMID:9140401 doi:10.1038/ng0597-88
  2. ↑ Silvaggi NR, Zhang C, Lu Z, Dai J, Dunaway-Mariano D, Allen KN. The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. Epub 2006 Mar 15. PMID:16540464 doi:http://dx.doi.org/10.1074/jbc.M601505200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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