Protein disulfide oxidoreductase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='DsbA (PDB entry [[3bci]])' scene='49/490083/Cv/1'> | <StructureSection load='' size='350' side='right' caption='DsbA (PDB entry [[3bci]])' scene='49/490083/Cv/1'> | ||
| + | __TOC__ | ||
== Function == | == Function == | ||
'''Protein disulfide oxidoreductase''' (PDOR) catalyzes disulfide bond formation in proteins and is critically important in protein folding. In bacteria PDOR are known as DsbA and DsbB. PDOR catalyze dithiol-disulfide exchange reactions, i.e., conversion of RSSR and R’SH to R’SSR’ and RSH<ref>PMID:15291821</ref>. | '''Protein disulfide oxidoreductase''' (PDOR) catalyzes disulfide bond formation in proteins and is critically important in protein folding. In bacteria PDOR are known as DsbA and DsbB. PDOR catalyze dithiol-disulfide exchange reactions, i.e., conversion of RSSR and R’SH to R’SSR’ and RSH<ref>PMID:15291821</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | PDOR DsnA contains the <scene name='49/490083/Cv/ | + | PDOR DsnA contains the <scene name='49/490083/Cv/3'>sequence CXXC</scene> in the active site. The 2 cysteines can undergo reversible oxidation-reduction in the catalytic process<ref>PMID:18007049</ref>. |
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==3D structures of protein disulfide oxidoreductase== | ==3D structures of protein disulfide oxidoreductase== | ||
| - | + | [[Protein disulfide oxidoreductase 3D structures]] | |
| - | [[1a8l]] – PDOR – ''Pyrococcus furiosus''<br /> | ||
| - | [[1bq7]] – EcDsbA (mutant) – ''Escherichia coli''<br /> | ||
| - | [[2hi7]], [[3e9j]], [[2zup]] - EcDsbA (mutant) + EcDsbB (mutant)<br /> | ||
| - | [[2leg]] - EcDsbA (mutant) + EcDsbB (mutant) - NMR<BR /> | ||
| - | [[2k73]], [[2k74]] - EcDsbB (mutant) - NMR<BR /> | ||
| - | [[1fo5]] – PDOR – ''Methanocaldococcus jannaschii'' – NMR<BR /> | ||
| - | [[2ayt]] – PDOR – ''Aquifex aeolicus''<br /> | ||
| - | [[2hls]] – PDOR – ''Aeropyrus pernix''<br /> | ||
| - | [[2rem]] - DsbA + peptide – ''Xylella fastidiosa''<br /> | ||
| - | [[1st9]], [[1su9]], [[2f9s]], [[2h1d]], [[3gha]] – BsResA soluble domain – ''Bacillus subtilis''<br /> | ||
| - | [[3eu3]] – BsBdbB<br /> | ||
| - | [[2h19]], [[2h1a]], [[2h1b]], [[2h1g]], [[3c71]], [[3c73]] - BsResA soluble domain (mutant) <br /> | ||
| - | [[4k6x]] – PDOR – ''Mycobacterium tuberculosis''<br /> | ||
| - | [[3bci]] – SaDsbA – ''Staphylococcus aureus''<br /> | ||
| - | [[3bck]], [[3bd2]] - SaDsbA (mutant) <br /> | ||
| - | [[3gh9]] - SaBdbB<br /> | ||
| - | [[3erw]] – SaPDOR sporulation<br /> | ||
| - | [[3fkf]] – PDOR – ''Bacterioides fragilis''<br /> | ||
| - | [[1bed]] – DsbA – ''Vibrio cholerae''<br /> | ||
| - | [[2zuq]], [[2ltq]] - EcDsbB (mutant) + antibody<br /> | ||
| - | [[4z7x]] - PDOR - ''Actinomyces oris''<br /> | ||
| - | [[5cnw]], [[5e59]] - DrPDOR - ''Deinicoccus radiodurans''<br /> | ||
| - | [[5cp1]] - DrPDOR (mutant)<br /> | ||
| - | [[4mcu]] - PDOR - ''Klebsiella pneumoniae''<br /> | ||
| - | [[4oce]] - PDOR - ''Proteus mirabillis''<br /> | ||
| - | [[4jrr]] - DsbA1 - ''Legionella pneumophila''<br /> | ||
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| + | For DsbB see [[Thiol:disulfide interchange protein]]. | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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