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| - | [[Image:1z3f.gif|left|200px]] | |
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| - | {{Structure
| + | ==Structure of ellipticine in complex with a 6-bp DNA== |
| - | |PDB= 1z3f |SIZE=350|CAPTION= <scene name='initialview01'>1z3f</scene>, resolution 1.50Å
| + | <StructureSection load='1z3f' size='340' side='right'caption='[[1z3f]], [[Resolution|resolution]] 1.50Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene>
| + | <table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3F FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | |GENE=
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene></td></tr> |
| - | |DOMAIN=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [https://pdbe.org/1z3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [https://www.ebi.ac.uk/pdbsum/1z3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3f ProSAT]</span></td></tr> |
| - | |RELATEDENTRY=
| + | </table> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [http://www.ebi.ac.uk/pdbsum/1z3f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB]</span>
| + | __TOC__ |
| - | }}
| + | </StructureSection> |
| - | | + | [[Category: Large Structures]] |
| - | '''Structure of ellipticine in complex with a 6-bp DNA'''
| + | [[Category: Aymami J]] |
| - | | + | [[Category: Canals A]] |
| - | | + | [[Category: Coll M]] |
| - | ==Overview==
| + | [[Category: Purciolas M]] |
| - | Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1Z3F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983425 15983425]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Aymami, J.]] | + | |
| - | [[Category: Canals, A.]] | + | |
| - | [[Category: Coll, M.]] | + | |
| - | [[Category: Purciolas, M.]] | + | |
| - | [[Category: anticancer]]
| + | |
| - | [[Category: dna binding]]
| + | |
| - | [[Category: drug design]]
| + | |
| - | [[Category: ellipticine]]
| + | |
| - | [[Category: intercalator]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:28:29 2008''
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