1z3y

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[[Image:1z3y.gif|left|200px]]
 
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{{Structure
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==Structure of Gun4-1 from Thermosynechococcus elongatus==
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|PDB= 1z3y |SIZE=350|CAPTION= <scene name='initialview01'>1z3y</scene>, resolution 1.70&Aring;
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<StructureSection load='1z3y' size='340' side='right'caption='[[1z3y]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1z3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus Thermosynechococcus vestitus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3Y FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= Gun4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=146786 Thermosynechococcus elongatus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3y OCA], [https://pdbe.org/1z3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3y RCSB], [https://www.ebi.ac.uk/pdbsum/1z3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3y ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1z3x|1Z3X]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3y OCA], [http://www.ebi.ac.uk/pdbsum/1z3y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z3y RCSB]</span>
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[https://www.uniprot.org/uniprot/Q8DIJ1_THEVB Q8DIJ1_THEVB]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Structure of Gun4-1 from Thermosynechococcus elongatus'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3y_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Gun4 has been implicated in a developmental signaling pathway between the chloroplast and the nucleus involving magnesium protoporphyrin IX (MgP(IX)), the first dedicated intermediate in the chlorophyll biosynthetic pathway. Here we present the crystal structure of Thermosynechococcus elongatus Gun4 at 1.5 A, describe the binding affinities of Gun4 for substrate and product porphyrin molecules, and identify a likely (Mg)P(IX) binding site on the protein. Kinetic analyses show that Gun4 dramatically increases the efficiency of transformation of porphyrin substrate to metalloporphyrin product and that it also reduces the threshold Mg2+ concentration required for activity at low porphyrin concentration. Gun4 therefore controls magnesium chelatase at physiologically significant Mg2+ concentrations and likely acts as a molecular switch in vivo so that in its absence magnesium chelatase is inactive. This mechanism could allow Gun4 to mediate magnesium protoporphyrin levels both for chlorophyll biosynthesis and for signaling to the nucleus.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3y ConSurf].
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1Z3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Y OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis., Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP, Hunter CN, Biochemistry. 2005 May 31;44(21):7603-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15909975 15909975]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Thermosynechococcus vestitus]]
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[[Category: Thermosynechococcus elongatus]]
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[[Category: Davison PA]]
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[[Category: Davison, P A.]]
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[[Category: Hill CP]]
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[[Category: Hill, C P.]]
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[[Category: Hunter CN]]
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[[Category: Hunter, C N.]]
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[[Category: Iorg CD]]
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[[Category: Iorg, C D.]]
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[[Category: Reid JD]]
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[[Category: Reid, J D.]]
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[[Category: Robinson H]]
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[[Category: Robinson, H.]]
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[[Category: Schubert HL]]
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[[Category: Schubert, H L.]]
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[[Category: transferase activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:28:44 2008''
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Current revision

Structure of Gun4-1 from Thermosynechococcus elongatus

PDB ID 1z3y

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