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5wkw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM)== | |
| + | <StructureSection load='5wkw' size='340' side='right'caption='[[5wkw]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WKW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wkw OCA], [https://pdbe.org/5wkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wkw RCSB], [https://www.ebi.ac.uk/pdbsum/5wkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wkw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AMD_RAT AMD_RAT] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. | ||
| - | + | ==See Also== | |
| - | + | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Gabelli | + | [[Category: Amzel LM]] |
| - | [[Category: | + | [[Category: Gabelli SB]] |
| + | [[Category: Maheshwari S]] | ||
| + | [[Category: Rudzka K]] | ||
Current revision
Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM)
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