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5ykj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems== | |
| - | + | <StructureSection load='5ykj' size='340' side='right'caption='[[5ykj]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ykj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRX1, YBL064C, YBL0503, YBL0524 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ykj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ykj OCA], [http://pdbe.org/5ykj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ykj RCSB], [http://www.ebi.ac.uk/pdbsum/5ykj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ykj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRX1_YEAST PRX1_YEAST]] Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Involved in mitochondrial protection of cadmium-induced oxidative stress.<ref>PMID:10821871</ref> <ref>PMID:19332553</ref> <ref>PMID:20059400</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Baker's yeast]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Peroxiredoxin]] | ||
| + | [[Category: Bao, R]] | ||
| + | [[Category: He, L H]] | ||
| + | [[Category: Li, C C]] | ||
| + | [[Category: Li, T]] | ||
[[Category: Liu, L]] | [[Category: Liu, L]] | ||
| - | [[Category: | + | [[Category: Peng, C T]] |
| - | [[Category: | + | [[Category: Song, Y J]] |
| - | [[Category: | + | [[Category: Yang, J]] |
| - | [[Category: | + | [[Category: Yang, M J]] |
| - | [[Category: | + | [[Category: Zhao, C]] |
| - | [[Category: | + | [[Category: Zhao, N L]] |
| - | [[Category: | + | [[Category: Zhu, Y B]] |
| + | [[Category: 1-cys peroxiredoxin]] | ||
| + | [[Category: Glutathione]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Thioredoxin]] | ||
| + | [[Category: Transferase]] | ||
Current revision
Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems
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Categories: Baker's yeast | Large Structures | Peroxiredoxin | Bao, R | He, L H | Li, C C | Li, T | Liu, L | Peng, C T | Song, Y J | Yang, J | Yang, M J | Zhao, C | Zhao, N L | Zhu, Y B | 1-cys peroxiredoxin | Glutathione | Saccharomyces cerevisiae | Thioredoxin | Transferase
