1z58

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[[Image:1z58.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a complex of the ribosome large subunit with rapamycin==
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|PDB= 1z58 |SIZE=350|CAPTION= <scene name='initialview01'>1z58</scene>, resolution 3.8&Aring;
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<StructureSection load='1z58' size='340' side='right'caption='[[1z58]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1z58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z58 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [https://pdbe.org/1z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [https://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z58 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1ond|1ond]], [[1p9x|1p9x]], [[1nkw|1nkw]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [http://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB]</span>
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}}
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'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
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==About this Structure==
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1Z58 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
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==Reference==
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A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15943964 15943964]
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Amit, M.]]
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[[Category: Amit M]]
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[[Category: Baram, D.]]
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[[Category: Baram D]]
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[[Category: Bashan, A.]]
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[[Category: Bashan A]]
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[[Category: Berisio, R.]]
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[[Category: Berisio R]]
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[[Category: Harms, J.]]
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[[Category: Harms J]]
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[[Category: Yonath, A.]]
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[[Category: Yonath A]]
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[[Category: polyketyde]]
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[[Category: ribosome]]
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[[Category: tunnel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:14 2008''
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Current revision

Crystal structure of a complex of the ribosome large subunit with rapamycin

PDB ID 1z58

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