1z56

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[[Image:1z56.gif|left|200px]]
 
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{{Structure
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==Co-Crystal Structure of Lif1p-Lig4p==
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|PDB= 1z56 |SIZE=350|CAPTION= <scene name='initialview01'>1z56</scene>, resolution 3.92&Aring;
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<StructureSection load='1z56' size='340' side='right'caption='[[1z56]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
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<table><tr><td colspan='2'>[[1z56]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z56 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
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|GENE= LIF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DNL4, LIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z56 OCA], [https://pdbe.org/1z56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z56 RCSB], [https://www.ebi.ac.uk/pdbsum/1z56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z56 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z56 OCA], [http://www.ebi.ac.uk/pdbsum/1z56 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z56 RCSB]</span>
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[https://www.uniprot.org/uniprot/DNLI4_YEAST DNLI4_YEAST] Has minor DNA joining activity. Can act on oligo(PDT)/poly(rA) substrate.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z56_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z56 ConSurf].
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<div style="clear:both"></div>
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'''Co-Crystal Structure of Lif1p-Lig4p'''
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the Xrcc4 'genome-guardian', an essential NHEJ factor. Here we report the 3.9 A crystal structure of the Saccharomyces cerevisiae Xrcc4 ortholog ligase interacting factor 1 (Lif1p) complexed with the C-terminal BRCT domains of DNA ligase IV (Lig4p). The structure reveals a novel mode of protein recognition by a tandem BRCT repeat, and in addition provides a molecular basis for a human LIG4 syndrome clinical condition.
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[[Category: Large Structures]]
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==About this Structure==
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1Z56 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z56 OCA].
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==Reference==
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Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16388993 16388993]
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[[Category: DNA ligase (ATP)]]
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[[Category: Protein complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Blundell, T L.]]
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[[Category: Blundell TL]]
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[[Category: Chirgadze, D Y.]]
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[[Category: Chirgadze DY]]
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[[Category: Davies, O R.]]
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[[Category: Davies OR]]
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[[Category: Dore, A S.]]
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[[Category: Dore AS]]
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[[Category: Furnham, N.]]
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[[Category: Furnham N]]
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[[Category: Jackson, S P.]]
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[[Category: Jackson SP]]
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[[Category: Pellegrini, L.]]
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[[Category: Pellegrini L]]
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[[Category: Sibanda, B L.]]
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[[Category: Sibanda BL]]
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[[Category: brct]]
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[[Category: coiled-coil]]
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[[Category: dna ligase]]
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[[Category: dna repair]]
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[[Category: nhej]]
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[[Category: xrcc4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:18 2008''
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Current revision

Co-Crystal Structure of Lif1p-Lig4p

PDB ID 1z56

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OCA

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