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5vkj

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==Crystal structure of human CD22 Ig domains 1-3==
==Crystal structure of human CD22 Ig domains 1-3==
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<StructureSection load='5vkj' size='340' side='right' caption='[[5vkj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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<StructureSection load='5vkj' size='340' side='right'caption='[[5vkj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vkj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vkj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VKJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vkm|5vkm]], [[5vkk|5vkk]], [[5vl3|5vl3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkj OCA], [http://pdbe.org/5vkj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkj RCSB], [http://www.ebi.ac.uk/pdbsum/5vkj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkj OCA], [https://pdbe.org/5vkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vkj RCSB], [https://www.ebi.ac.uk/pdbsum/5vkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD22_HUMAN CD22_HUMAN]] Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
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[https://www.uniprot.org/uniprot/CD22_HUMAN CD22_HUMAN] Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ereno-Orbea, J]]
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[[Category: Homo sapiens]]
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[[Category: Julien, J P]]
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[[Category: Large Structures]]
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[[Category: Sicard, T]]
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[[Category: Ereno-Orbea J]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Julien JP]]
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[[Category: Immune system]]
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[[Category: Sicard T]]
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[[Category: Sialic acid]]
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[[Category: Siglec]]
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Current revision

Crystal structure of human CD22 Ig domains 1-3

PDB ID 5vkj

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