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1z7n

From Proteopedia

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[[Image:1z7n.gif|left|200px]]
 
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{{Structure
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==ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate==
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|PDB= 1z7n |SIZE=350|CAPTION= <scene name='initialview01'>1z7n</scene>, resolution 3.25&Aring;
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<StructureSection load='1z7n' size='340' side='right'caption='[[1z7n]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene>
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<table><tr><td colspan='2'>[[1z7n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z7N FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_phosphoribosyltransferase ATP phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.17 2.4.2.17] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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|GENE= hisZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis]), hisG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7n OCA], [https://pdbe.org/1z7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z7n RCSB], [https://www.ebi.ac.uk/pdbsum/1z7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z7n ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1z7m|1Z7M]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z7n OCA], [http://www.ebi.ac.uk/pdbsum/1z7n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z7n RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/HISZ_LACLA HISZ_LACLA] Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.[HAMAP-Rule:MF_00125]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z7/1z7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z7n ConSurf].
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<div style="clear:both"></div>
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'''ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate'''
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==See Also==
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*[[ATP Phosphoribosyl Transferase|ATP Phosphoribosyl Transferase]]
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*[[ATP phosphoribosyl transferase 3D structures|ATP phosphoribosyl transferase 3D structures]]
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==About this Structure==
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__TOC__
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1Z7N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7N OCA].
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</StructureSection>
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[[Category: ATP phosphoribosyltransferase]]
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[[Category: Lactococcus lactis]]
[[Category: Lactococcus lactis]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Champagne, K S.]]
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[[Category: Champagne KS]]
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[[Category: Doublie, S.]]
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[[Category: Doublie S]]
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[[Category: Francklyn, C S.]]
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[[Category: Francklyn CS]]
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[[Category: Larrabee, Y.]]
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[[Category: Larrabee Y]]
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[[Category: Sissler, M.]]
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[[Category: Sissler M]]
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[[Category: allosteric]]
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[[Category: atp-prt]]
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[[Category: histidine biosynthesis]]
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[[Category: hiszg]]
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[[Category: prpp]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:23 2008''
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Current revision

ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis with bound PRPP substrate

PDB ID 1z7n

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