1z8d

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[[Image:1z8d.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose==
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|PDB= 1z8d |SIZE=350|CAPTION= <scene name='initialview01'>1z8d</scene>, resolution 2.30&Aring;
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<StructureSection load='1z8d' size='340' side='right'caption='[[1z8d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>
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<table><tr><td colspan='2'>[[1z8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8D FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= PYGM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [https://pdbe.org/1z8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB], [https://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8d ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2gpa|2GPA]], [[7gpb|7GPB]], [[3amv|3AMV]], [[1fa9|1FA9]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8d OCA], [http://www.ebi.ac.uk/pdbsum/1z8d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z8d RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Defects in PYGM are the cause of glycogen storage disease type 5 (GSD5) [MIM:[https://omim.org/entry/232600 232600]; also known as McArdle disease. GSD5 is a metabolic disorder resulting in myopathy characterized by exercise intolerance, cramps, muscle weakness and recurrent myoglobinuria.<ref>PMID:8316268</ref> <ref>PMID:8535454</ref> <ref>PMID:7603523</ref> <ref>PMID:9506549</ref> <ref>PMID:10417800</ref> <ref>PMID:10382911</ref> <ref>PMID:10382912</ref> <ref>PMID:10681080</ref> <ref>PMID:10590419</ref> <ref>PMID:10714589</ref> <ref>PMID:10899452</ref> <ref>PMID:11706962</ref> <ref>PMID:12031624</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PYGM_HUMAN PYGM_HUMAN] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8d ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose'''
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==See Also==
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*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: McArdle disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608455 608455]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1Z8D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8D OCA].
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==Reference==
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The crystal structure of human muscle glycogen phosphorylase a with bound glucose and AMP: an intermediate conformation with T-state and R-state features., Lukacs CM, Oikonomakos NG, Crowther RL, Hong LN, Kammlott RU, Levin W, Li S, Liu CM, Lucas-McGady D, Pietranico S, Reik L, Proteins. 2006 Jun 1;63(4):1123-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16523484 16523484]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Crowther RL]]
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[[Category: Crowther, R L.]]
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[[Category: Hong LN]]
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[[Category: Hong, L N.]]
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[[Category: Kammlott RU]]
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[[Category: Kammlott, R U.]]
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[[Category: Levin W]]
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[[Category: Levin, W.]]
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[[Category: Li S]]
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[[Category: Li, S.]]
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[[Category: Liu CM]]
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[[Category: Liu, C M.]]
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[[Category: Lucas-McGady D]]
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[[Category: Lucas-McGady, D.]]
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[[Category: Lukacs CM]]
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[[Category: Lukacs, C M.]]
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[[Category: Oikonomakos NG]]
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[[Category: Oikonomakos, N G.]]
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[[Category: Pietranico S]]
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[[Category: Pietranico, S.]]
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[[Category: Reik L]]
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[[Category: Reik, L.]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:58 2008''
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Current revision

Crystal Structure of Human Muscle Glycogen Phosphorylase a with AMP and Glucose

PDB ID 1z8d

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