1z8f

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[[Image:1z8f.gif|left|200px]]
 
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{{Structure
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==Guanylate Kinase Double Mutant A58C, T157C from Mycobacterium tuberculosis (Rv1389)==
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|PDB= 1z8f |SIZE=350|CAPTION= <scene name='initialview01'>1z8f</scene>, resolution 2.50&Aring;
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<StructureSection load='1z8f' size='340' side='right'caption='[[1z8f]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>
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<table><tr><td colspan='2'>[[1z8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8F FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE= gmk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00071 GMPK]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8f OCA], [https://pdbe.org/1z8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8f RCSB], [https://www.ebi.ac.uk/pdbsum/1z8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8f ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1s4q|1S4Q]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8f OCA], [http://www.ebi.ac.uk/pdbsum/1z8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z8f RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KGUA_MYCTU KGUA_MYCTU] Essential for recycling GMP and indirectly, cGMP (By similarity).[HAMAP-Rule:MF_00328]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8f ConSurf].
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<div style="clear:both"></div>
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'''Guanylate Kinase Double Mutant A58C, T157C from Mycobacterium tuberculosis (Rv1389)'''
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==See Also==
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*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1Z8F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8F OCA].
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[[Category: Large Structures]]
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[[Category: Guanylate kinase]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Chan S]]
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[[Category: Chan, S.]]
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[[Category: Choi B]]
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[[Category: Choi, B.]]
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[[Category: Perry LJ]]
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[[Category: Perry, L J.]]
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[[Category: Sawaya MR]]
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[[Category: Sawaya, M R.]]
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[[Category: Zocchi G]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
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[[Category: Zocchi, G.]]
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[[Category: atp:gmp-phosphotransferase]]
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[[Category: mycobacterium tuberculosis structural proteomics project]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: xmtb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:31:59 2008''
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Current revision

Guanylate Kinase Double Mutant A58C, T157C from Mycobacterium tuberculosis (Rv1389)

PDB ID 1z8f

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