3bor

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==Crystal structure of the DEADc domain of human translation initiation factor 4A-2==
==Crystal structure of the DEADc domain of human translation initiation factor 4A-2==
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<StructureSection load='3bor' size='340' side='right' caption='[[3bor]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='3bor' size='340' side='right'caption='[[3bor]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BOR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOR FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF4A2, DDX2B, EIF4F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bor OCA], [http://pdbe.org/3bor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bor RCSB], [http://www.ebi.ac.uk/pdbsum/3bor PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bor ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bor OCA], [https://pdbe.org/3bor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bor RCSB], [https://www.ebi.ac.uk/pdbsum/3bor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bor ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IF4A2_HUMAN IF4A2_HUMAN]] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
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[https://www.uniprot.org/uniprot/IF4A2_HUMAN IF4A2_HUMAN] ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/3bor_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/3bor_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3bor" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3bor" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Dimov, S]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Dimov S]]
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[[Category: Hong, B]]
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[[Category: Edwards AM]]
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[[Category: Karlberg, T]]
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[[Category: Hong B]]
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[[Category: MacKenzie, F]]
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[[Category: Karlberg T]]
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[[Category: Park, H]]
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[[Category: MacKenzie F]]
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[[Category: Structural genomic]]
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[[Category: Park H]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Atp-binding]]
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[[Category: Dead box]]
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[[Category: Helicase]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Initiation factor]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein biosynthesis]]
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[[Category: Rna-binding]]
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[[Category: Sgc]]
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[[Category: Translation initiation]]
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Current revision

Crystal structure of the DEADc domain of human translation initiation factor 4A-2

PDB ID 3bor

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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