3c6h

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==Crystal Structure of the RB49 gp17 nuclease domain==
==Crystal Structure of the RB49 gp17 nuclease domain==
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<StructureSection load='3c6h' size='340' side='right' caption='[[3c6h]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3c6h' size='340' side='right'caption='[[3c6h]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3c6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteriophage_rb49 Bacteriophage rb49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3c6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB49 Escherichia phage RB49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C6H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c6a|3c6a]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=50948 Bacteriophage RB49])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6h OCA], [https://pdbe.org/3c6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c6h RCSB], [https://www.ebi.ac.uk/pdbsum/3c6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6h OCA], [http://pdbe.org/3c6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3c6h RCSB], [http://www.ebi.ac.uk/pdbsum/3c6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6h ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9T1C3_BPRB4 Q9T1C3_BPRB4] The terminase large subunit acts as an ATP driven molecular motor necessary for viral DNA translocation into empty capsids and as an endonuclease that cuts the viral genome to initiate and to end a packaging reaction. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (packaging sequence), and a large terminase subunit possessing endonucleolytic and ATPase activities. Both terminase subunits heterooligomerize and are docked on the portal protein to form the packaging machine. The terminase large subunit exhibits endonuclease activity and cleaves the viral genome concatemer. Once the capsid is packaged with the DNA, the terminase complex is substituted by the tail.[HAMAP-Rule:MF_04146]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c6h_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c6h_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3c6h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3c6h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Terminase 3D Structures|Terminase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacteriophage rb49]]
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[[Category: Escherichia phage RB49]]
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[[Category: Rossmann, M G]]
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[[Category: Large Structures]]
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[[Category: Sun, S]]
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[[Category: Rossmann MG]]
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[[Category: Terminase nuclease]]
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[[Category: Sun S]]
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[[Category: Viral protein]]
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Current revision

Crystal Structure of the RB49 gp17 nuclease domain

PDB ID 3c6h

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