3dwr

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==Leishmania major coproporphyrinogen III oxidase with bound ligand==
==Leishmania major coproporphyrinogen III oxidase with bound ligand==
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<StructureSection load='3dwr' size='340' side='right' caption='[[3dwr]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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<StructureSection load='3dwr' size='340' side='right'caption='[[3dwr]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dwr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DWR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dwr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DWR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0PA:CYCLOPENTYLACETIC+ACID'>0PA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qt8|2qt8]], [[1vju|1vju]], [[3dws|3dws]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0PA:CYCLOPENTYLACETIC+ACID'>0PA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LMAJ006828, LmjF06.1270 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwr OCA], [https://pdbe.org/3dwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dwr RCSB], [https://www.ebi.ac.uk/pdbsum/3dwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coproporphyrinogen_oxidase Coproporphyrinogen oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.3 1.3.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dwr OCA], [http://pdbe.org/3dwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3dwr RCSB], [http://www.ebi.ac.uk/pdbsum/3dwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3dwr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HEM6_LEIMA HEM6_LEIMA]] Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).[HAMAP-Rule:MF_00333]
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[https://www.uniprot.org/uniprot/HEM6_LEIMA HEM6_LEIMA] Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).[HAMAP-Rule:MF_00333]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/3dwr_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Coproporphyrinogen oxidase]]
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[[Category: Large Structures]]
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[[Category: Leima]]
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[[Category: Leishmania major]]
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[[Category: Merritt, E A]]
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[[Category: Le Trong I]]
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[[Category: Structural genomic]]
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[[Category: Merritt EA]]
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[[Category: Trong, I Le]]
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[[Category: Fragment cocktail]]
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[[Category: Heme biosynthesis]]
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[[Category: Oxidoreductase]]
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[[Category: Porphyrin biosynthesis]]
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[[Category: Sgpp]]
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Current revision

Leishmania major coproporphyrinogen III oxidase with bound ligand

PDB ID 3dwr

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