3lmo

<StructureSection load='3lmo' size='340' side='right' caption='[[3lmo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[3lmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"rhodobacillus_palustris"_molisch_1907 "rhodobacillus palustris" molisch 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LMO FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RPA2022 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1076 "Rhodobacillus palustris" Molisch 1907])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lmo OCA], [http://pdbe.org/3lmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lmo RCSB], [http://www.ebi.ac.uk/pdbsum/3lmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lmo ProSAT]</span></td></tr>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lmo_consurf.spt"</scriptWhenChecked>

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== Publication Abstract from PubMed ==

The solution nuclear magnetic resonance (NMR) structures and backbone (15)N dynamics of the specialized acyl carrier protein (ACP), RpAcpXL, from Rhodopseudomonas palustris, in both the apo form and holo form modified by covalent attachment of 4'-phosphopantetheine at S37, are virtually identical, monomeric, and correspond to the closed conformation. The structures have an extra alpha-helix compared to the archetypical ACP from Escherichia coli, which has four helices, resulting in a larger opening to the hydrophobic cavity. Chemical shift differences between apo- and holo-RpAcpXL indicated some differences in the hinge region between alpha2 and alpha3 and in the hydrophobic cavity environment, but corresponding changes in nuclear Overhauser effect cross-peak patterns were not detected. In contrast to the NMR structures, apo-RpAcpXL was observed in an open conformation in crystals that diffracted to 2.0 A resolution, which resulted from movement of alpha3. On the basis of the crystal structure, the predicted biological assembly is a homodimer. Although the possible biological significance of dimerization is unknown, there is potential that the resulting large shared hydrophobic cavity could accommodate the very long-chain fatty acid (28-30 carbons) that this specialized ACP is known to synthesize and transfer to lipid A. These structures are the first representatives of the AcpXL family and the first to indicate that dimerization may be important for the function of these specialized ACPs.

 

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== References ==

[[Category: Rhodobacillus palustris molisch 1907]]

[[Category: Acton, T B]]

[[Category: Ciccosanti, C]]

[[Category: Everett, J K]]

[[Category: Forouhar, F]]

[[Category: Hunt, J F]]

[[Category: Lew, S]]

[[Category: Mao, M]]

[[Category: Montelione, G T]]

[[Category: Structural genomic]]

[[Category: Nair, R]]

[[Category: Rossi, P]]

[[Category: Rost, B]]

[[Category: Seetharaman, J]]

[[Category: Tong, L]]

[[Category: Wang, H]]

[[Category: Xiao, R]]

[[Category: Transferase]]