Ribosome recycling factor

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<StructureSection load='1ek8' size='340' side='right' caption='E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code [[1ek8]])' scene='70/706271/Cv/1' pspeed='8'>
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<StructureSection load='' size='340' side='right' caption='E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code [[1ek8]])' scene='70/706271/Cv/1' pspeed='8'>
== Function ==
== Function ==
'''Ribosome recycling factor''' (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis.
'''Ribosome recycling factor''' (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis.
RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation<ref>PMID:16043510</ref>. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA.
RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation<ref>PMID:16043510</ref>. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA.
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*<scene name='70/706271/Cv/2'>1st Hg coordination site</scene>.
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*<scene name='70/706271/Cv/4'>1st Hg coordination site</scene>.
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*<scene name='70/706271/Cv/3'>2nd and 3rd Hg coordination sites</scene>. Water molecule shown as red sphere.
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*<scene name='70/706271/Cv/5'>2nd and 3rd Hg coordination sites</scene>. Water molecule is shown as red sphere.
</StructureSection>
</StructureSection>
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*Ribosome recycling factor
*Ribosome recycling factor
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**[[1wih]] – RRF mitochondrial domain II – mouse - NMR <br />
**[[1dd5]] – RRF – ''Thermotoga maritima'' <br />
**[[1dd5]] – RRF – ''Thermotoga maritima'' <br />
**[[1eh1]] – TtRRF – ''Thermus thermophilus'' <br />
**[[1eh1]] – TtRRF – ''Thermus thermophilus'' <br />
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**[[1is1]] – RRF – ''Vibrio parahaemolyticus'' <br />
**[[1is1]] – RRF – ''Vibrio parahaemolyticus'' <br />
**[[1wqf]], [[1wqg]], [[1wqh]], [[4kdd]] – MtRRF - ''Mycobacterium tuberculosis''<br />
**[[1wqf]], [[1wqg]], [[1wqh]], [[4kdd]] – MtRRF - ''Mycobacterium tuberculosis''<br />
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**[[1kb2]], [[4kb4]], [[4kc6]], [[4kaw]] – MtRRF (mutant) <br />
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**[[4kb2]], [[4kb4]], [[4kc6]], [[4kaw]] – MtRRF (mutant) <br />
**[[4gfq]] – RRF – ''Bacillus anthracis'' <br />
**[[4gfq]] – RRF – ''Bacillus anthracis'' <br />
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**[[1wih]] – RRF mitochondrial domain II – mouse - NMR <br />
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**[[6vud]] – RRF – ''Ehrlichia chafeensis''<br />
*Ribosome recycling factor in the ribosome
*Ribosome recycling factor in the ribosome
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**[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF + part of 50S ribosome <br />
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**[[6nu2]], [[6nu3]], [[6zs9]], [[7l20]], [[7nsi]], [[7nsh]] – hRRF in 38S ribosome – human - Cryo-EM <br />
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**[[1t1m]], [[1zn1]] – EcRRF + part of 70S ribosome – Cryo-EM <br />
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**[[7l08]], [[7nqh]], [[7nql]], [[7nsj]] – hRRF in 55S mitoribosome - Cryo-EM <br />
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**[[1zn0]], [[2rdo]] – EcRRF + part of 50S ribosome – Cryo-EM <br />
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**[[5mlc]], [[6eri]] – RRF in 50S ribosome – spinach - Cryo-EM <br />
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**[[3j0d]], [[3j0e]] – TtRRF + part of Ec50S ribosome – Cryo-EM <br />
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**[[4v54]], [[4v55]], [[4v5y]], [[4v9c]], [[4v9d]] – EcRRF in 50S ribosome <br />
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**[[4v5a]] – TtRRF + part of 70S ribosome <br />
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**[[1t1m]], [[1zn1]] – EcRRF in 70S ribosome – Cryo-EM <br />
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**[[1y69]] – RRF + part of 50S ribosome – ''Deinococcus radiodurans'' <br />
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**[[1zn0]], [[2rdo]] – EcRRF in 50S ribosome – Cryo-EM <br />
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**[[4woi]] – EcRRF in 50S ribosome + antibiotic <br />
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**[[3j0d]], [[3j0e]] – TtRRF in Ec50S ribosome – Cryo-EM <br />
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**[[4v5a]], [[6ucq]] – TtRRF in 70S ribosome <br />
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**[[1y69]] – RRF in 50S ribosome – ''Deinococcus radiodurans'' <br />
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**[[7pau]] – RRF in 50S ribosome – ''Mycoplasma pneumoniae'' - Cryo-EM <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code 1ek8)

Drag the structure with the mouse to rotate

3D Structures of ribosome recycling factor

Updated on 31-October-2023

References

  1. ↑ Hirokawa G, Nijman RM, Raj VS, Kaji H, Igarashi K, Kaji A. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA. 2005 Aug;11(8):1317-28. PMID:16043510 doi:http://dx.doi.org/10.1261/rna.2520405

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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