Virion infectivity factor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code [[2ma9]])' scene='75/750233/Cv/1'> |
== Function == | == Function == | ||
| - | Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. | + | '''Virion infectivity factor''' (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/4'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. |
For details see [[HIV and accessory proteins]] | For details see [[HIV and accessory proteins]] | ||
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</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[4n9f]] – | + | [[4n9f]] – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – HIV-1<br /> |
| - | [[2ma9]], [[3dcg]] – Vif + elongin-C + elongin-B – | + | [[8fvi]], [[8fvj]] – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – Cryo EM<br /> |
| + | [[2ma9]], [[3dcg]] – HIVVif + elongin-C + elongin-B <br /> | ||
| + | [[6nil]] – HIVVif + CBF-β + AF3 - Cryo EM<br /> | ||
| + | [[8cx0]], [[8cx1]], [[8cx2]] – HIVVif + elongin-C + elongin-B + CBF-β + RNA – Cryo EM<br /> | ||
| + | [[8e40]] – HIVVif + deoxycytidine deaminase + CBF-β + RNA – Cryo EM<br /> | ||
| + | [[6p59]] – Vif + elongin-C + elongin-B + CBF-β – SIV-1<br /> | ||
| + | [[7upn]] – Vif + elongin-C + elongin-B + PPIase A – Visna-Maedi virus – Cryo EM<br /> | ||
| - | == References == | + | == References == |
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of virion infectivity factor
Updated on 19-March-2024
4n9f – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – HIV-1
8fvi, 8fvj – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – Cryo EM
2ma9, 3dcg – HIVVif + elongin-C + elongin-B
6nil – HIVVif + CBF-β + AF3 - Cryo EM
8cx0, 8cx1, 8cx2 – HIVVif + elongin-C + elongin-B + CBF-β + RNA – Cryo EM
8e40 – HIVVif + deoxycytidine deaminase + CBF-β + RNA – Cryo EM
6p59 – Vif + elongin-C + elongin-B + CBF-β – SIV-1
7upn – Vif + elongin-C + elongin-B + PPIase A – Visna-Maedi virus – Cryo EM
References
- ↑ Rose KM, Marin M, Kozak SL, Kabat D. The viral infectivity factor (Vif) of HIV-1 unveiled. Trends Mol Med. 2004 Jun;10(6):291-7. PMID:15177194 doi:http://dx.doi.org/10.1016/j.molmed.2004.04.008
