1zig

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[[Image:1zig.gif|left|200px]]
 
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{{Structure
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==GAGA RNA TETRALOOP, NMR, 10 STRUCTURES==
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|PDB= 1zig |SIZE=350|CAPTION= <scene name='initialview01'>1zig</scene>
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<StructureSection load='1zig' size='340' side='right'caption='[[1zig]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1zig]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZIG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [https://pdbe.org/1zig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB], [https://www.ebi.ac.uk/pdbsum/1zig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zig ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=[[1zif|1ZIF]], [[1zih|1ZIH]]
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<div style="background-color:#fffaf0;">
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zig OCA], [http://www.ebi.ac.uk/pdbsum/1zig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zig RCSB]</span>
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== Publication Abstract from PubMed ==
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}}
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'''GAGA RNA TETRALOOP, NMR, 10 STRUCTURES'''
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==Overview==
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RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
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==About this Structure==
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A network of heterogeneous hydrogen bonds in GNRA tetraloops.,Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624<ref>PMID:9000624</ref>
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1ZIG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIG OCA].
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==Reference==
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A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9000624 9000624]
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[[Category: Protein complex]]
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[[Category: Heus, H A.]]
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[[Category: Jucker, F M.]]
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[[Category: Moors, E.]]
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[[Category: Pardi, A.]]
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[[Category: Yip, P F.]]
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[[Category: gnra]]
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[[Category: hairpin]]
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[[Category: ribonucleic acid]]
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[[Category: rna]]
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[[Category: tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:37:03 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1zig" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Heus HA]]
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[[Category: Jucker FM]]
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[[Category: Moors E]]
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[[Category: Pardi A]]
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[[Category: Yip PF]]

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GAGA RNA TETRALOOP, NMR, 10 STRUCTURES

PDB ID 1zig

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