6bf2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6bf2 is ON HOLD Authors: Viacava Follis, A., Phillips, A., Kriwacki, R.K. Description: Solution structure of a Bcl-xL S62E mutant [[Category: Unrel...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a Bcl-xL S62E mutant== | |
| + | <StructureSection load='6bf2' size='340' side='right'caption='[[6bf2]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [https://pdbe.org/6bf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Intrinsically disordered regions (IDRs) of proteins often regulate function upon post-translational modification (PTM) through interactions with folded domains. An IDR linking two alpha-helices (alpha1-alpha2) of the antiapoptotic protein Bcl-xL experiences several PTMs that reduce antiapoptotic activity. Here, we report that PTMs within the alpha1-alpha2 IDR promote its interaction with the folded core of Bcl-xL that inhibits the proapoptotic activity of two types of regulatory targets, BH3-only proteins and p53. This autoregulation utilizes an allosteric pathway whereby, in one direction, the IDR induces a direct displacement of p53 from Bcl-xL coupled to allosteric displacement of simultaneously bound BH3-only partners. This pathway operates in the opposite direction when the BH3-only protein PUMA binds to the BH3 binding groove of Bcl-xL, directly displacing other bound BH3-only proteins, and allosterically remodels the distal site, displacing p53. Our findings show how an IDR enhances functional versatility through PTM-dependent allosteric regulation of a folded protein domain. | ||
| - | + | Regulation of apoptosis by an intrinsically disordered region of Bcl-xL.,Follis AV, Llambi F, Kalkavan H, Yao Y, Phillips AH, Park CG, Marassi FM, Green DR, Kriwacki RW Nat Chem Biol. 2018 Mar 5. pii: 10.1038/s41589-018-0011-x. doi:, 10.1038/s41589-018-0011-x. PMID:29507390<ref>PMID:29507390</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Kriwacki | + | <div class="pdbe-citations 6bf2" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kriwacki RW]] | ||
| + | [[Category: Phillips A]] | ||
| + | [[Category: Viacava Follis A]] | ||
Current revision
Solution structure of a Bcl-xL S62E mutant
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