6bf6

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(New page: '''Unreleased structure''' The entry 6bf6 is ON HOLD Authors: Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J. Descri...)
Current revision (14:21, 13 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6bf6 is ON HOLD
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==Cryo-EM structure of human insulin degrading enzyme==
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<SX load='6bf6' size='340' side='right' viewer='molstar' caption='[[6bf6]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bf6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BF6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf6 OCA], [https://pdbe.org/6bf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bf6 RCSB], [https://www.ebi.ac.uk/pdbsum/6bf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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Authors: Liang, W.G., Zhang, Z., Bailey, L.J., Kossiakoff, A.A., Tan, Y.Z., Wei, H., Carragher, B., Potter, S.C., Tang, W.J.
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==See Also==
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
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Description: Cryo-EM structure of human insulin degrading enzyme in complex with insulin
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Tan, Y.Z]]
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__TOC__
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[[Category: Kossiakoff, A.A]]
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</SX>
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[[Category: Carragher, B]]
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[[Category: Homo sapiens]]
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[[Category: Zhang, Z]]
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[[Category: Large Structures]]
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[[Category: Wei, H]]
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[[Category: Bailey LJ]]
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[[Category: Liang, W.G]]
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[[Category: Carragher B]]
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[[Category: Bailey, L.J]]
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[[Category: Kossiakoff AA]]
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[[Category: Potter, S.C]]
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[[Category: Liang WG]]
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[[Category: Tang, W.J]]
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[[Category: Potter SC]]
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[[Category: Tan YZ]]
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[[Category: Tang WJ]]
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[[Category: Wei H]]
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[[Category: Zhang Z]]

Current revision

Cryo-EM structure of human insulin degrading enzyme

6bf6, resolution 6.50Å

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