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| | ==Crystal structure of YEATS2 YEATS bound to H3K27ac peptide== | | ==Crystal structure of YEATS2 YEATS bound to H3K27ac peptide== |
| - | <StructureSection load='5xnv' size='340' side='right' caption='[[5xnv]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='5xnv' size='340' side='right'caption='[[5xnv]], [[Resolution|resolution]] 2.70Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XNV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5xnv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XNV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.696Å</td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [http://pdbe.org/5xnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [http://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnv OCA], [https://pdbe.org/5xnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xnv RCSB], [https://www.ebi.ac.uk/pdbsum/5xnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnv ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/YETS2_HUMAN YETS2_HUMAN]] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<ref>PMID:19103755</ref> | + | [https://www.uniprot.org/uniprot/YETS2_HUMAN YETS2_HUMAN] Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<ref>PMID:19103755</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Guan, H P]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Li, H T]] | + | [[Category: Large Structures]] |
| - | [[Category: Zhao, D]] | + | [[Category: Guan HP]] |
| - | [[Category: Epigenetic]] | + | [[Category: Li HT]] |
| - | [[Category: Histone acetylation]] | + | [[Category: Zhao D]] |
| - | [[Category: Histone reader]]
| + | |
| - | [[Category: Protein binding-peptide complex]]
| + | |
| - | [[Category: Protein complex]]
| + | |
| Structural highlights
Function
YETS2_HUMAN Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.[1]
Publication Abstract from PubMed
Recognition of modified histones by "reader" proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS domain-containing proteins in human cancer remains largely unknown. Here, we show that the YEATS2 gene is highly amplified in human non-small cell lung cancer (NSCLC) and is required for cancer cell growth and survival. YEATS2 binds to acetylated histone H3 via its YEATS domain. The YEATS2-containing ATAC complex co-localizes with H3K27 acetylation (H3K27ac) on the promoters of actively transcribed genes. Depletion of YEATS2 or disruption of the interaction between its YEATS domain and acetylated histones reduces the ATAC complex-dependent promoter H3K9ac levels and deactivates the expression of essential genes. Taken together, our study identifies YEATS2 as a histone H3K27ac reader that regulates a transcriptional program essential for NSCLC tumorigenesis.
YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.,Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4. PMID:29057918[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Mol Cell Biol. 2009 Mar;29(5):1176-88. doi: 10.1128/MCB.01599-08. Epub 2008 Dec, 22. PMID:19103755 doi:10.1128/MCB.01599-08
- ↑ Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi X. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun. 2017 Oct 20;8(1):1088. doi: 10.1038/s41467-017-01173-4. PMID:29057918 doi:http://dx.doi.org/10.1038/s41467-017-01173-4
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