1zmq

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[[Image:1zmq.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human alpha-defensin-6==
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|PDB= 1zmq |SIZE=350|CAPTION= <scene name='initialview01'>1zmq</scene>, resolution 2.10&Aring;
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<StructureSection load='1zmq' size='340' side='right'caption='[[1zmq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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<table><tr><td colspan='2'>[[1zmq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZMQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= DEFA6, DEF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zmq OCA], [https://pdbe.org/1zmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zmq RCSB], [https://www.ebi.ac.uk/pdbsum/1zmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zmq ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1dfn|1DFN]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zmq OCA], [http://www.ebi.ac.uk/pdbsum/1zmq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zmq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DEF6_HUMAN DEF6_HUMAN] Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.<ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Six alpha-defensins have been found in humans. These small arginine-rich peptides play important roles in various processes related to host defense, being the effectors and regulators of innate immunity as well as enhancers of adoptive immune responses. Four defensins, called neutrophil peptides 1 through 4, are stored primarily in polymorphonuclear leukocytes. Major sites of expression of defensins 5 and 6 are Paneth cells of human small intestine. So far, only one structure of human alpha-defensin (HNP3) has been reported, and the properties of the intestine defensins 5 and 6 are particularly poorly understood. In this report, we present the high-resolution X-ray structures of three human defensins, 4 through 6, supplemented with studies of their antimicrobial and chemotactic properties. Despite only modest amino acid sequence identity, all three defensins share their tertiary structures with other known alpha- and beta-defensins. Like HNP3 but in contrast to murine or rabbit alpha-defensins, human defensins 4-6 form characteristic dimers. Whereas antimicrobial and chemotactic activity of HNP4 is somewhat comparable to that of other human neutrophil defensins, neither of the intestinal defensins appears to be chemotactic, and for HD6 also an antimicrobial activity has yet to be observed. The unusual biological inactivity of HD6 may be associated with its structural properties, somewhat standing out when compared with other human alpha-defensins. The strongest cationic properties and unique distribution of charged residues on the molecular surface of HD5 may be associated with its highest bactericidal activity among human alpha-defensins.
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'''Crystal structure of human alpha-defensin-6'''
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Crystal structures of human alpha-defensins HNP4, HD5, and HD6.,Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6. PMID:17088326<ref>PMID:17088326</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1zmq" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Six alpha-defensins have been found in humans. These small arginine-rich peptides play important roles in various processes related to host defense, being the effectors and regulators of innate immunity as well as enhancers of adoptive immune responses. Four defensins, called neutrophil peptides 1 through 4, are stored primarily in polymorphonuclear leukocytes. Major sites of expression of defensins 5 and 6 are Paneth cells of human small intestine. So far, only one structure of human alpha-defensin (HNP3) has been reported, and the properties of the intestine defensins 5 and 6 are particularly poorly understood. In this report, we present the high-resolution X-ray structures of three human defensins, 4 through 6, supplemented with studies of their antimicrobial and chemotactic properties. Despite only modest amino acid sequence identity, all three defensins share their tertiary structures with other known alpha- and beta-defensins. Like HNP3 but in contrast to murine or rabbit alpha-defensins, human defensins 4-6 form characteristic dimers. Whereas antimicrobial and chemotactic activity of HNP4 is somewhat comparable to that of other human neutrophil defensins, neither of the intestinal defensins appears to be chemotactic, and for HD6 also an antimicrobial activity has yet to be observed. The unusual biological inactivity of HD6 may be associated with its structural properties, somewhat standing out when compared with other human alpha-defensins. The strongest cationic properties and unique distribution of charged residues on the molecular surface of HD5 may be associated with its highest bactericidal activity among human alpha-defensins.
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*[[Defensin 3D structures|Defensin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1ZMQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMQ OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structures of human alpha-defensins HNP4, HD5, and HD6., Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J, Protein Sci. 2006 Dec;15(12):2749-60. Epub 2006 Nov 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17088326 17088326]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lu, W.]]
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[[Category: Lu W]]
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[[Category: Lubkowski, J.]]
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[[Category: Lubkowski J]]
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[[Category: Szyk, A.]]
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[[Category: Szyk A]]
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[[Category: antimicrobial]]
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[[Category: human intestinal alpha-defensin]]
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[[Category: paneth cells defensin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:49 2008''
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Current revision

Crystal structure of human alpha-defensin-6

PDB ID 1zmq

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