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==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase== | ==The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase== | ||
| - | <StructureSection load='3ffs' size='340' side='right' caption='[[3ffs]], [[Resolution|resolution]] 3.19Å' scene=''> | + | <StructureSection load='3ffs' size='340' side='right'caption='[[3ffs]], [[Resolution|resolution]] 3.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ffs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FFS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ffs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ffs OCA], [https://pdbe.org/3ffs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ffs RCSB], [https://www.ebi.ac.uk/pdbsum/3ffs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ffs ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/3ffs_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3ffs" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Cryptosporidium parvum]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Aquino | + | [[Category: D'Aquino JA]] |
| - | [[Category: Hedstrom | + | [[Category: Hedstrom L]] |
| - | [[Category: Lu | + | [[Category: Lu J]] |
| - | [[Category: Petsko | + | [[Category: Petsko GA]] |
| - | [[Category: Riera | + | [[Category: Riera TV]] |
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Current revision
The Crystal Structure of Cryptosporidium parvum Inosine-5'-Monophosphate Dehydrogenase
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