This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3gph

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:09, 6 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid==
==Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid==
-
<StructureSection load='3gph' size='340' side='right' caption='[[3gph]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='3gph' size='340' side='right'caption='[[3gph]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3gph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPH FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3gph]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GPH FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OID:10-(1H-IMIDAZOL-1-YL)DECANOIC+ACID'>OID</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e6i|3e6i]], [[3e4e|3e4e]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OID:10-(1H-IMIDAZOL-1-YL)DECANOIC+ACID'>OID</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2E, CYP2E1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gph OCA], [https://pdbe.org/3gph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gph RCSB], [https://www.ebi.ac.uk/pdbsum/3gph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gph ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gph OCA], [http://pdbe.org/3gph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gph RCSB], [http://www.ebi.ac.uk/pdbsum/3gph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gph ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CP2E1_HUMAN CP2E1_HUMAN]] Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
+
[https://www.uniprot.org/uniprot/CP2E1_HUMAN CP2E1_HUMAN] Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gph_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gph_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 31: Line 29:
</div>
</div>
<div class="pdbe-citations 3gph" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gph" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Unspecific monooxygenase]]
+
[[Category: Large Structures]]
-
[[Category: Battaile, K P]]
+
[[Category: Battaile KP]]
-
[[Category: Porubsky, P R]]
+
[[Category: Porubsky PR]]
-
[[Category: Scott, E E]]
+
[[Category: Scott EE]]
-
[[Category: Acetaminophen]]
+
-
[[Category: Cyp2e1]]
+
-
[[Category: Fatty acid hydroxylase]]
+
-
[[Category: Heme]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Monooxygenase]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: P450 2e1]]
+

Current revision

Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid

PDB ID 3gph

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3gph"
Personal tools