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3gwu

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==Leucine transporter LeuT in complex with sertraline==
==Leucine transporter LeuT in complex with sertraline==
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<StructureSection load='3gwu' size='340' side='right' caption='[[3gwu]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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<StructureSection load='3gwu' size='340' side='right'caption='[[3gwu]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SRE:(1S,4S)-4-(3,4-DICHLOROPHENYL)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE'>SRE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gwv|3gwv]], [[3gww|3gww]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SRE:(1S,4S)-4-(3,4-DICHLOROPHENYL)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE'>SRE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwu OCA], [https://pdbe.org/3gwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwu RCSB], [https://www.ebi.ac.uk/pdbsum/3gwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwu OCA], [http://pdbe.org/3gwu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gwu RCSB], [http://www.ebi.ac.uk/pdbsum/3gwu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwu ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwu_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwu_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3gwu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gwu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Leucine transporter|Leucine transporter]]
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*[[Serotonin Transporter|Serotonin Transporter]]
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*[[Symporter 3D structures|Symporter 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aquae]]
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[[Category: Aquifex aeolicus VF5]]
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[[Category: Karpowich, N K]]
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[[Category: Large Structures]]
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[[Category: Law, C J]]
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[[Category: Karpowich NK]]
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[[Category: Reith, M E.A]]
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[[Category: Law CJ]]
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[[Category: Wang, D N]]
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[[Category: Reith MEA]]
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[[Category: Zhen, J]]
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[[Category: Wang DN]]
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[[Category: Zhou, Z]]
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[[Category: Zhen J]]
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[[Category: Antidepressant]]
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[[Category: Zhou Z]]
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[[Category: Integral membrane protein]]
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[[Category: Neurotransmitter]]
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[[Category: Nss]]
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[[Category: Symport]]
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[[Category: Transmembrane]]
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[[Category: Transmembrane transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

Leucine transporter LeuT in complex with sertraline

PDB ID 3gwu

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OCA

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