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3h5c
From Proteopedia
(Difference between revisions)
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==X-Ray Structure of Protein Z-Protein Z Inhibitor Complex== | ==X-Ray Structure of Protein Z-Protein Z Inhibitor Complex== | ||
| - | <StructureSection load='3h5c' size='340' side='right' caption='[[3h5c]], [[Resolution|resolution]] 3.26Å' scene=''> | + | <StructureSection load='3h5c' size='340' side='right'caption='[[3h5c]], [[Resolution|resolution]] 3.26Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3h5c]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3h5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H5C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SERPINA10, ZPI, UNQ707/PRO1358 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SERPINA10, ZPI, UNQ707/PRO1358 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h5c OCA], [https://pdbe.org/3h5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h5c RCSB], [https://www.ebi.ac.uk/pdbsum/3h5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h5c ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ZPI_HUMAN ZPI_HUMAN]] Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. [[https://www.uniprot.org/uniprot/PROZ_HUMAN PROZ_HUMAN]] Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/3h5c_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/3h5c_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3h5c" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3h5c" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Serpin 3D structures|Serpin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Dementiev, A A]] | [[Category: Dementiev, A A]] | ||
[[Category: Gettins, P G.W]] | [[Category: Gettins, P G.W]] | ||
Current revision
X-Ray Structure of Protein Z-Protein Z Inhibitor Complex
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Categories: Homo sapiens | Human | Large Structures | Dementiev, A A | Gettins, P G.W | Huang, X | Olson, S T | Blood coagulation | Cleavage on pair of basic residue | Disulfide bond | Egf-like domain | Gamma-carboxyglutamic acid | Glycoprotein | Hydrolase inhibitor-blood clotting complex | Hydroxylation | Protease inhibitor | Protein z-protein z inhibitor complex | Secreted | Serine protease homolog | Serine protease inhibitor
