3ibp

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==The Crystal Structure of the Dimerization Domain of Escherichia coli Structural Maintenance of Chromosomes Protein MukB==
==The Crystal Structure of the Dimerization Domain of Escherichia coli Structural Maintenance of Chromosomes Protein MukB==
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<StructureSection load='3ibp' size='340' side='right' caption='[[3ibp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='3ibp' size='340' side='right'caption='[[3ibp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ibp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IBP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ibp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.099&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0924, JW0907, mukB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ibp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ibp OCA], [https://pdbe.org/3ibp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ibp RCSB], [https://www.ebi.ac.uk/pdbsum/3ibp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ibp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ibp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ibp OCA], [http://pdbe.org/3ibp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ibp RCSB], [http://www.ebi.ac.uk/pdbsum/3ibp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ibp ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI]] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/3ibp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/3ibp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 3ibp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ibp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Condensin|Condensin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Berger, J M]]
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[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Berger JM]]
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[[Category: Oakley, M G]]
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[[Category: Li Y]]
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[[Category: Schoeffler, A J]]
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[[Category: Oakley MG]]
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[[Category: Atp-binding]]
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[[Category: Schoeffler AJ]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Chromosome partition]]
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[[Category: Chromosome segregation]]
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[[Category: Cohesin]]
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[[Category: Condensin]]
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[[Category: Dimerization domain]]
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[[Category: Dna condensation]]
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[[Category: Dna-binding]]
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[[Category: Hinge]]
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[[Category: Mukb]]
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[[Category: Nucleotide-binding]]
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[[Category: Smc]]
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[[Category: Structural maintenance of chromosome]]
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Current revision

The Crystal Structure of the Dimerization Domain of Escherichia coli Structural Maintenance of Chromosomes Protein MukB

PDB ID 3ibp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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