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3ifa

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==Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP==
==Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP==
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<StructureSection load='3ifa' size='340' side='right' caption='[[3ifa]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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<StructureSection load='3ifa' size='340' side='right'caption='[[3ifa]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ifa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IFA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ifa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IFA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ifc|3ifc]], [[1eyj|1eyj]], [[1eyk|1eyk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">8789 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ifa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifa OCA], [https://pdbe.org/3ifa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ifa RCSB], [https://www.ebi.ac.uk/pdbsum/3ifa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifa ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ifa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ifa OCA], [http://pdbe.org/3ifa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ifa RCSB], [http://www.ebi.ac.uk/pdbsum/3ifa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ifa ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/F16P2_HUMAN F16P2_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifa_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/3ifa_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3ifa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ifa" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fructose-bisphosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Dzugaj, A]]
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[[Category: Dzugaj A]]
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[[Category: Jaskolski, M]]
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[[Category: Jaskolski M]]
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[[Category: Kolodziejczyk, R]]
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[[Category: Kolodziejczyk R]]
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[[Category: Zarzycki, M]]
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[[Category: Zarzycki M]]
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[[Category: 6-bisphosphatase]]
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[[Category: Allosteric enzyme]]
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[[Category: Calcium inhibition]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Gluconeogenesis]]
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[[Category: Glyconeogenesis]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Muscle fructose-1]]
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[[Category: Phosphoprotein]]
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[[Category: Protein engineering]]
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Current revision

Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP

PDB ID 3ifa

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