1zr3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:12, 23 August 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1zr3.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)==
-
|PDB= 1zr3 |SIZE=350|CAPTION= <scene name='initialview01'>1zr3</scene>, resolution 1.66&Aring;
+
<StructureSection load='1zr3' size='340' side='right'caption='[[1zr3]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>
+
<table><tr><td colspan='2'>[[1zr3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZR3 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr3 OCA], [https://pdbe.org/1zr3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zr3 RCSB], [https://www.ebi.ac.uk/pdbsum/1zr3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zr3 ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1zq0|1ZQ0]], [[1zr5|1ZR5]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zr3 OCA], [http://www.ebi.ac.uk/pdbsum/1zr3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zr3 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/H2AY_HUMAN H2AY_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.<ref>PMID:12718888</ref> <ref>PMID:15621527</ref> <ref>PMID:15897469</ref> <ref>PMID:16428466</ref> <ref>PMID:16107708</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zr3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zr3 ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)'''
+
==See Also==
-
 
+
*[[Histone 3D structures|Histone 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1ZR3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZR3 OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
-
Getting a grip on O-acetyl-ADP-ribose., Hoff KG, Wolberger C, Nat Struct Mol Biol. 2005 Jul;12(7):560-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15999106 15999106]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hothorn, M.]]
+
[[Category: Hothorn M]]
-
[[Category: Kustatscher, G.]]
+
[[Category: Kustatscher G]]
-
[[Category: Ladurner, A G.]]
+
[[Category: Ladurner AG]]
-
[[Category: Pugieux, C.]]
+
[[Category: Pugieux C]]
-
[[Category: Scheffzek, K.]]
+
[[Category: Scheffzek K]]
-
[[Category: a1pp]]
+
-
[[Category: chromatin]]
+
-
[[Category: histone]]
+
-
[[Category: macro-domain]]
+
-
[[Category: p-loop]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:32 2008''
+

Current revision

Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)

PDB ID 1zr3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zr3"
Personal tools