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3l8w

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==Urate oxidase from aspergillus flavus complexed with xanthin==
==Urate oxidase from aspergillus flavus complexed with xanthin==
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<StructureSection load='3l8w' size='340' side='right' caption='[[3l8w]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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<StructureSection load='3l8w' size='340' side='right'caption='[[3l8w]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfl Aspfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3l8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L8W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PO:ALPHA-(4-PYRIDYL-1-OXIDE)-N-TERT-BUTYLNITRONE'>4PO</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XAN:XANTHINE'>XAN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r51|1r51]], [[1r4s|1r4s]], [[1r4u|1r4u]], [[1r56|1r56]], [[1wrr|1wrr]], [[1xt4|1xt4]], [[3l9g|3l9g]], [[3lbg|3lbg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [https://pdbe.org/3l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [https://www.ebi.ac.uk/pdbsum/3l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8w ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Factor_independent_urate_hydroxylase Factor independent urate hydroxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8w OCA], [http://pdbe.org/3l8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l8w RCSB], [http://www.ebi.ac.uk/pdbsum/3l8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8w ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL]] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
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[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8w_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8w_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3l8w" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspfl]]
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[[Category: Aspergillus flavus]]
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[[Category: Factor independent urate hydroxylase]]
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[[Category: Large Structures]]
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[[Category: Chiadmi, M]]
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[[Category: Chiadmi M]]
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[[Category: Gabison, L]]
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[[Category: Colloc'h N]]
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[[Category: H, N Colloc]]
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[[Category: Gabison L]]
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[[Category: Prange, T]]
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[[Category: Prange T]]
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[[Category: Inhibition aspergillus flavus]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisome]]
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[[Category: Purine metabolism]]
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[[Category: Uric acid degradation]]
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[[Category: Xanthine]]
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Current revision

Urate oxidase from aspergillus flavus complexed with xanthin

PDB ID 3l8w

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