5a1i

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==The structure of Human MAT2A in complex with SAMe, Adenosine, Methionine and PPNP.==
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==The structure of Human MAT2A in complex with SAM, Adenosine, Methionine and PPNP.==
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<StructureSection load='5a1i' size='340' side='right' caption='[[5a1i]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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<StructureSection load='5a1i' size='340' side='right'caption='[[5a1i]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a1i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A1I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a1i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PPK:(DIPHOSPHONO)AMINOPHOSPHONIC+ACID'>PPK</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a19|5a19]], [[5a1g|5a1g]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PPK:(DIPHOSPHONO)AMINOPHOSPHONIC+ACID'>PPK</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1i OCA], [https://pdbe.org/5a1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1i RCSB], [https://www.ebi.ac.uk/pdbsum/5a1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1i OCA], [http://pdbe.org/5a1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a1i RCSB], [http://www.ebi.ac.uk/pdbsum/5a1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1i ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
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[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5a1i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a1i" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Methionine adenosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Antonyuk, S V]]
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[[Category: Antonyuk SV]]
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[[Category: Hasnain, S S]]
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[[Category: Hasnain SS]]
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[[Category: Lu, S C]]
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[[Category: Lu SC]]
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[[Category: Marina, A]]
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[[Category: Marina A]]
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[[Category: Mato, J M]]
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[[Category: Mato JM]]
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[[Category: Murray, B]]
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[[Category: Murray B]]
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[[Category: Rojas, A L]]
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[[Category: Rojas AL]]
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[[Category: Cell growth]]
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[[Category: Liver cancer]]
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[[Category: Methylation]]
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[[Category: Transferase]]
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Current revision

The structure of Human MAT2A in complex with SAM, Adenosine, Methionine and PPNP.

PDB ID 5a1i

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