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5cyo
From Proteopedia
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==High resolution Septin 9 GTPase domain in complex with GDP== | ==High resolution Septin 9 GTPase domain in complex with GDP== | ||
| - | <StructureSection load='5cyo' size='340' side='right' caption='[[5cyo]], [[Resolution|resolution]] 2.04Å' scene=''> | + | <StructureSection load='5cyo' size='340' side='right'caption='[[5cyo]], [[Resolution|resolution]] 2.04Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cyo]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5cyo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CYO FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0354Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | < | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyo OCA], [https://pdbe.org/5cyo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cyo RCSB], [https://www.ebi.ac.uk/pdbsum/5cyo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyo ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Neuralgic amyotrophy. A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.<ref>PMID:10339604</ref> The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SEPT9_HUMAN SEPT9_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Araujo | + | [[Category: Large Structures]] |
| - | [[Category: Garratt | + | [[Category: Araujo APU]] |
| - | [[Category: Horjales | + | [[Category: Garratt RC]] |
| - | [[Category: Leonardo | + | [[Category: Horjales E]] |
| - | [[Category: Matos | + | [[Category: Leonardo DA]] |
| - | [[Category: Pereira | + | [[Category: Matos SS]] |
| - | + | [[Category: Pereira HM]] | |
| - | + | ||
Current revision
High resolution Septin 9 GTPase domain in complex with GDP
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