This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5e6i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:14, 5 July 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of TCR PF8 in complex with flu MP(58-66) epitope presented by HLA-A2==
==Crystal structure of TCR PF8 in complex with flu MP(58-66) epitope presented by HLA-A2==
-
<StructureSection load='5e6i' size='340' side='right' caption='[[5e6i]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+
<StructureSection load='5e6i' size='340' side='right'caption='[[5e6i]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5e6i]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E6I FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5e6i]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Boston/2747243M/2009(H1N1)) Influenza A virus (A/Boston/2747243M/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E6I FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2M, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TRBC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6i OCA], [http://pdbe.org/5e6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e6i RCSB], [http://www.ebi.ac.uk/pdbsum/5e6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e6i ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e6i OCA], [https://pdbe.org/5e6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e6i RCSB], [https://www.ebi.ac.uk/pdbsum/5e6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e6i ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.
+
[https://www.uniprot.org/uniprot/K7N5M3_HUMAN K7N5M3_HUMAN]
-
== References ==
+
 
-
<references/>
+
==See Also==
 +
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 +
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Gao, M]]
+
[[Category: Large Structures]]
-
[[Category: Mariuzza, R]]
+
[[Category: Gao M]]
-
[[Category: Complex]]
+
[[Category: Mariuzza R]]
-
[[Category: Flu]]
+
-
[[Category: Hla-a2]]
+
-
[[Category: Immune system]]
+
-
[[Category: Tcr]]
+

Current revision

Crystal structure of TCR PF8 in complex with flu MP(58-66) epitope presented by HLA-A2

PDB ID 5e6i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5e6i"
Personal tools