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5ujc
From Proteopedia
(Difference between revisions)
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==Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue== | ==Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue== | ||
| - | <StructureSection load='5ujc' size='340' side='right' caption='[[5ujc]], [[Resolution|resolution]] 1.35Å' scene=''> | + | <StructureSection load='5ujc' size='340' side='right'caption='[[5ujc]], [[Resolution|resolution]] 1.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ujc]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5ujc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJC FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COB:CO-METHYLCOBALAMIN'>COB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COB:CO-METHYLCOBALAMIN'>COB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ujc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujc OCA], [https://pdbe.org/5ujc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ujc RCSB], [https://www.ebi.ac.uk/pdbsum/5ujc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujc ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MMAC_CAEEL MMAC_CAEEL] Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives.[UniProtKB:Q9Y4U1] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Caenorhabditis elegans]] |
| - | [[Category: Banerjee | + | [[Category: Large Structures]] |
| - | [[Category: Brunold | + | [[Category: Banerjee R]] |
| - | [[Category: Koutmos | + | [[Category: Brunold TC]] |
| - | [[Category: Krautler | + | [[Category: Koutmos M]] |
| - | [[Category: Lesniak | + | [[Category: Krautler B]] |
| - | [[Category: Li | + | [[Category: Lesniak NA]] |
| - | [[Category: Ruetz | + | [[Category: Li Z]] |
| - | [[Category: Shanmuganathan | + | [[Category: Ruetz M]] |
| - | [[Category: Yamada | + | [[Category: Shanmuganathan A]] |
| - | + | [[Category: Yamada K]] | |
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Current revision
Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue
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