1oey

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==Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase==
==Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase==
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<StructureSection load='1oey' size='340' side='right' caption='[[1oey]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1oey' size='340' side='right'caption='[[1oey]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1oey]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OEY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1oey]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OEY FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e96|1e96]], [[1hh8|1hh8]], [[1ip9|1ip9]], [[1ipg|1ipg]], [[1k4u|1k4u]], [[1h6h|1h6h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oey OCA], [http://pdbe.org/1oey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oey RCSB], [http://www.ebi.ac.uk/pdbsum/1oey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oey ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oey OCA], [https://pdbe.org/1oey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oey RCSB], [https://www.ebi.ac.uk/pdbsum/1oey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oey ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Defects in NCF4 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 3 (CGD3) [MIM:[https://omim.org/entry/613960 613960]. CGD3 is a disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:19692703</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/NCF4_HUMAN NCF4_HUMAN] Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oey_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oe/1oey_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1oey" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1oey" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gill, D J]]
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[[Category: Large Structures]]
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[[Category: Perisic, O]]
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[[Category: Gill DJ]]
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[[Category: Quinn, M T]]
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[[Category: Perisic O]]
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[[Category: Williams, R L]]
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[[Category: Quinn MT]]
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[[Category: Wilson, M I]]
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[[Category: Williams RL]]
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[[Category: Heterodimerization]]
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[[Category: Wilson MI]]
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[[Category: Immune system]]
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[[Category: Nadph oxidase]]
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[[Category: Pb1 domain]]
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[[Category: Pb1 heterodimer-complex]]
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Current revision

Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase

PDB ID 1oey

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