1zvm

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[[Image:1zvm.gif|left|200px]]
 
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{{Structure
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==Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase==
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|PDB= 1zvm |SIZE=350|CAPTION= <scene name='initialview01'>1zvm</scene>, resolution 2.20&Aring;
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<StructureSection load='1zvm' size='340' side='right'caption='[[1zvm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1zvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZVM FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE= CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvm OCA], [https://pdbe.org/1zvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zvm RCSB], [https://www.ebi.ac.uk/pdbsum/1zvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zvm ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zvm OCA], [http://www.ebi.ac.uk/pdbsum/1zvm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zvm RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zvm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zvm ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase'''
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==See Also==
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*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1ZVM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVM OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: NAD(+) nucleosidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Sauve A]]
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[[Category: Sauve, A.]]
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[[Category: Schramm VL]]
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[[Category: Schramm, V L.]]
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[[Category: Shi W]]
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[[Category: Shi, W.]]
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[[Category: Yang T]]
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[[Category: Yang, T.]]
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[[Category: adpr cyclase]]
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[[Category: dimer]]
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[[Category: nad hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:42:13 2008''
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Current revision

Crystal structure of human CD38: cyclic-ADP-ribosyl synthetase/NAD+ glycohydrolase

PDB ID 1zvm

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