5uvg
From Proteopedia
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==Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound== | ==Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound== | ||
| - | <StructureSection load='5uvg' size='340' side='right' caption='[[5uvg]], [[Resolution|resolution]] 1.85Å' scene=''> | + | <StructureSection load='5uvg' size='340' side='right'caption='[[5uvg]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5uvg]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5uvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UVG FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uvg OCA], [https://pdbe.org/5uvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uvg RCSB], [https://www.ebi.ac.uk/pdbsum/5uvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uvg ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NSMA2_HUMAN NSMA2_HUMAN] Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.<ref>PMID:10823942</ref> <ref>PMID:14741383</ref> <ref>PMID:15051724</ref> |
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| + | ==See Also== | ||
| + | *[[Sphingomyelinase|Sphingomyelinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Airola | + | [[Category: Large Structures]] |
| - | [[Category: Garcia-Diaz | + | [[Category: Airola MV]] |
| - | [[Category: Guja | + | [[Category: Garcia-Diaz M]] |
| - | [[Category: Hannun | + | [[Category: Guja KE]] |
| - | + | [[Category: Hannun YA]] | |
| - | + | ||
Current revision
Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound
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