This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4wh7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:31, 27 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Structure of the CDC25B Phosphatase Catalytic Domain with Bound Ligand==
==Structure of the CDC25B Phosphatase Catalytic Domain with Bound Ligand==
-
<StructureSection load='4wh7' size='340' side='right' caption='[[4wh7]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
+
<StructureSection load='4wh7' size='340' side='right'caption='[[4wh7]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4wh7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4wh7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WH7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8H8:2-FLUORO-4-HYDROXYBENZONITRILE'>8H8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh9|4wh9]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8H8:2-FLUORO-4-HYDROXYBENZONITRILE'>8H8</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC25B, CDC25HU2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh7 OCA], [https://pdbe.org/4wh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4wh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wh7 ProSAT]</span></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh7 OCA], [http://pdbe.org/4wh7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wh7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wh7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wh7 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN]] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
+
[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 19:
</div>
</div>
<div class="pdbe-citations 4wh7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wh7" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 +
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Large Structures]]
-
[[Category: Borkin, D]]
+
[[Category: Borkin D]]
-
[[Category: Cierpicki, T]]
+
[[Category: Cierpicki T]]
-
[[Category: Dudkin, S]]
+
[[Category: Dudkin S]]
-
[[Category: Grembecka, J]]
+
[[Category: Grembecka J]]
-
[[Category: Lund, G L]]
+
[[Category: Lund GL]]
-
[[Category: Ni, W]]
+
[[Category: Ni W]]
-
[[Category: Fragment]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Phosphatase]]
+

Current revision

Structure of the CDC25B Phosphatase Catalytic Domain with Bound Ligand

PDB ID 4wh7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4wh7"
Personal tools