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4x9j

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==EGR-1 with Doubly Methylated DNA==
==EGR-1 with Doubly Methylated DNA==
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<StructureSection load='4x9j' size='340' side='right' caption='[[4x9j]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
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<StructureSection load='4x9j' size='340' side='right'caption='[[4x9j]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x9j]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X9J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x9j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X9J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.412&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r2a|4r2a]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x9j OCA], [https://pdbe.org/4x9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x9j RCSB], [https://www.ebi.ac.uk/pdbsum/4x9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x9j ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGR1, KROX24, ZNF225 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x9j OCA], [http://pdbe.org/4x9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x9j RCSB], [http://www.ebi.ac.uk/pdbsum/4x9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x9j ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EGR1_HUMAN EGR1_HUMAN]] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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[https://www.uniprot.org/uniprot/EGR1_HUMAN EGR1_HUMAN] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Iwahara, J]]
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[[Category: Large Structures]]
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[[Category: White, M A]]
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[[Category: Synthetic construct]]
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[[Category: Zandarashvili, L]]
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[[Category: Iwahara J]]
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[[Category: Dna binding]]
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[[Category: White MA]]
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[[Category: Methylated dna]]
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[[Category: Zandarashvili L]]
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[[Category: Transcription]]
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[[Category: Transcription regulator-dna complex]]
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[[Category: Zinc finger]]
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Current revision

EGR-1 with Doubly Methylated DNA

PDB ID 4x9j

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