4cwn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:15, 9 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
==Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor==
-
<StructureSection load='4cwn' size='340' side='right' caption='[[4cwn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+
<StructureSection load='4cwn' size='340' side='right'caption='[[4cwn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4cwn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWN FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4cwn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CWN FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LV:5-(3,5-DIMETHOXYBENZYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>6LV</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwf|4cwf]], [[4cwo|4cwo]], [[4cwp|4cwp]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LV:5-(3,5-DIMETHOXYBENZYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-2-AMINE'>6LV</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwn OCA], [http://pdbe.org/4cwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cwn RCSB], [http://www.ebi.ac.uk/pdbsum/4cwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwn ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwn OCA], [https://pdbe.org/4cwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cwn RCSB], [https://www.ebi.ac.uk/pdbsum/4cwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cwn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
+
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 4cwn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4cwn" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Amboldi, N]]
+
[[Category: Homo sapiens]]
-
[[Category: Brasca, G]]
+
[[Category: Large Structures]]
-
[[Category: Caronni, D]]
+
[[Category: Amboldi N]]
-
[[Category: Casale, E]]
+
[[Category: Brasca G]]
-
[[Category: Casuscelli, F]]
+
[[Category: Caronni D]]
-
[[Category: Colombo, N]]
+
[[Category: Casale E]]
-
[[Category: Dalvit, C]]
+
[[Category: Casuscelli F]]
-
[[Category: Felder, E R]]
+
[[Category: Colombo N]]
-
[[Category: Fogliatto, G]]
+
[[Category: Dalvit C]]
-
[[Category: Isacchi, A]]
+
[[Category: Felder ER]]
-
[[Category: Mantegani, S]]
+
[[Category: Fogliatto G]]
-
[[Category: Polucci, P]]
+
[[Category: Isacchi A]]
-
[[Category: Riceputi, L]]
+
[[Category: Mantegani S]]
-
[[Category: Sola, F]]
+
[[Category: Polucci P]]
-
[[Category: Visco, C]]
+
[[Category: Riceputi L]]
-
[[Category: Zuccotto, F]]
+
[[Category: Sola F]]
-
[[Category: Chaperone]]
+
[[Category: Visco C]]
 +
[[Category: Zuccotto F]]

Current revision

Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

PDB ID 4cwn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cwn"
Personal tools