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| - | [[Image:205d.jpg|left|200px]] | |
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| - | {{Structure
| + | ==STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP== |
| - | |PDB= 205d |SIZE=350|CAPTION= <scene name='initialview01'>205d</scene>, resolution 2.640Å
| + | <StructureSection load='205d' size='340' side='right'caption='[[205d]], [[Resolution|resolution]] 2.64Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>
| + | <table><tr><td colspan='2'>[[205d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=205D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=205D FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=205d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=205d OCA], [https://pdbe.org/205d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=205d RCSB], [https://www.ebi.ac.uk/pdbsum/205d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=205d ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=205d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=205d OCA], [http://www.ebi.ac.uk/pdbsum/205d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=205d RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Baeyens KJ]] |
| - | '''STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP'''
| + | [[Category: De Bondt HL]] |
| - | | + | [[Category: Holbrook SR]] |
| - | | + | |
| - | ==Overview==
| + | |
| - | The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 205D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=205D OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Structure of an RNA double helix including uracil-uracil base pairs in an internal loop., Baeyens KJ, De Bondt HL, Holbrook SR, Nat Struct Biol. 1995 Jan;2(1):56-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7719854 7719854]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Baeyens, K J.]] | + | |
| - | [[Category: Bondt, H L.De.]] | + | |
| - | [[Category: Holbrook, S R.]] | + | |
| - | [[Category: a-rna]]
| + | |
| - | [[Category: double helix]]
| + | |
| - | [[Category: internal loop]]
| + | |
| - | [[Category: mismatched]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:44:06 2008''
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