5jnn

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==Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid.==
==Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid.==
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<StructureSection load='5jnn' size='340' side='right' caption='[[5jnn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5jnn' size='340' side='right'caption='[[5jnn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jnn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JNN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LM:(3S,4E)-5-[(1R,5R,8S)-8-HYDROXY-1,5-DIMETHYL-3-OXO-6-OXABICYCLO[3.2.1]OCTAN-8-YL]-3-METHYLPENT-4-ENOIC+ACID'>6LM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jo1|5jo1]], [[5jo2|5jo2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LM:(3S,4E)-5-[(1R,5R,8S)-8-HYDROXY-1,5-DIMETHYL-3-OXO-6-OXABICYCLO[3.2.1]OCTAN-8-YL]-3-METHYLPENT-4-ENOIC+ACID'>6LM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnn OCA], [http://pdbe.org/5jnn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnn RCSB], [http://www.ebi.ac.uk/pdbsum/5jnn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnn OCA], [https://pdbe.org/5jnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jnn RCSB], [https://www.ebi.ac.uk/pdbsum/5jnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
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[https://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Classically, hormones elicit specific cellular responses by activating dedicated receptors. Nevertheless, the biosynthesis and turnover of many of these hormone molecules also produce chemically related metabolites. These molecules may also possess hormonal activities; therefore, one or more may contribute to the adaptive plasticity of signaling outcomes in host organisms. Here, we show that a catabolite of the plant hormone abscisic acid (ABA), namely phaseic acid (PA), likely emerged in seed plants as a signaling molecule that fine-tunes plant physiology, environmental adaptation, and development. This trait was facilitated by both the emergence-selection of a PA reductase that modulates PA concentrations and by the functional diversification of the ABA receptor family to perceive and respond to PA. Our results suggest that PA serves as a hormone in seed plants through activation of a subset of ABA receptors. This study demonstrates that the co-evolution of hormone metabolism and signaling networks can expand organismal resilience.
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Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity.,Weng JK, Ye M, Li B, Noel JP Cell. 2016 Aug 11;166(4):881-93. doi: 10.1016/j.cell.2016.06.027. PMID:27518563<ref>PMID:27518563</ref>
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==See Also==
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*[[Abscisic acid receptor 3D structures|Abscisic acid receptor 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5jnn" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Noel, J P]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Weng, J K]]
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[[Category: Large Structures]]
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[[Category: Aba receptor]]
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[[Category: Noel JP]]
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[[Category: Phaseic acid]]
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[[Category: Weng JK]]
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[[Category: Pyr/pyl]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of abscisic acid receptor PYL2 in complex with Phaseic acid.

PDB ID 5jnn

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