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5jq9

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==Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16==
==Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16==
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<StructureSection load='5jq9' size='340' side='right' caption='[[5jq9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5jq9' size='340' side='right'caption='[[5jq9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jq9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_KIM_D27 Yersinia pestis KIM D27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JQ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6MB:4-{[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]AMINO}-N-(3,4-DIMETHYL-1,2-OXAZOL-5-YL)BENZENE-1-SULFONAMIDE'>6MB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.101&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MB:4-{[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]AMINO}-N-(3,4-DIMETHYL-1,2-OXAZOL-5-YL)BENZENE-1-SULFONAMIDE'>6MB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jq9 OCA], [http://pdbe.org/5jq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jq9 RCSB], [http://www.ebi.ac.uk/pdbsum/5jq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jq9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jq9 OCA], [https://pdbe.org/5jq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jq9 RCSB], [https://www.ebi.ac.uk/pdbsum/5jq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jq9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A2S9PLG4_YERPE A0A2S9PLG4_YERPE] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[RuleBase:RU361205]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jq9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jq9" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydropteroate synthase]]
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[[Category: Large Structures]]
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[[Category: White, S W]]
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[[Category: Yersinia pestis KIM D27]]
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[[Category: Wu, Y]]
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[[Category: White SW]]
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[[Category: Antibiotic]]
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[[Category: Wu Y]]
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[[Category: Dihydropteroate synthesis]]
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[[Category: Pterine-sulfa conjugate]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16

PDB ID 5jq9

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