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244d

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[[Image:244d.jpg|left|200px]]
 
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{{Structure
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==THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX==
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|PDB= 244d |SIZE=350|CAPTION= <scene name='initialview01'>244d</scene>, resolution 1.200&Aring;
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<StructureSection load='244d' size='340' side='right'caption='[[244d]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[244d]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=244D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [https://pdbe.org/244d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=244d RCSB], [https://www.ebi.ac.uk/pdbsum/244d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=244d ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=244d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=244d OCA], [http://www.ebi.ac.uk/pdbsum/244d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=244d RCSB]</span>
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__TOC__
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}}
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</StructureSection>
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[[Category: Large Structures]]
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'''THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX'''
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[[Category: Laughlan G]]
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[[Category: Lilley DMJ]]
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[[Category: Luisi B]]
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==Overview==
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[[Category: Moody PCE]]
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Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
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[[Category: Moore MH]]
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[[Category: Murchie AIH]]
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==About this Structure==
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[[Category: Norman DG]]
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244D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=244D OCA].
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==Reference==
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The high-resolution crystal structure of a parallel-stranded guanine tetraplex., Laughlan G, Murchie AI, Norman DG, Moore MH, Moody PC, Lilley DM, Luisi B, Science. 1994 Jul 22;265(5171):520-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8036494 8036494]
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[[Category: Protein complex]]
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[[Category: Laughlan, G.]]
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[[Category: Lilley, D M.J.]]
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[[Category: Luisi, B.]]
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[[Category: Moody, P C.E.]]
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[[Category: Moore, M H.]]
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[[Category: Murchie, A I.H.]]
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[[Category: Norman, D G.]]
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[[Category: parallel-stranded tetraplex]]
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[[Category: quadruple helix]]
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[[Category: unusual dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:06 2008''
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Current revision

THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX

PDB ID 244d

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