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5t9y

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==Crystal structure of the infectious salmon anemia virus (ISAV) hemagglutinin-esterase protein==
==Crystal structure of the infectious salmon anemia virus (ISAV) hemagglutinin-esterase protein==
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<StructureSection load='5t9y' size='340' side='right' caption='[[5t9y]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5t9y' size='340' side='right'caption='[[5t9y]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t9y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Isav Isav]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T9Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t9y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmon_isavirus Salmon isavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T9Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5t96|5t96]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=55987 ISAV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9y OCA], [https://pdbe.org/5t9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t9y RCSB], [https://www.ebi.ac.uk/pdbsum/5t9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9y OCA], [http://pdbe.org/5t9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t9y RCSB], [http://www.ebi.ac.uk/pdbsum/5t9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9y ProSAT]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9J0Y0_9ORTO Q9J0Y0_9ORTO]
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Orthomyxoviruses are an important family of RNA viruses, which include the various influenza viruses. Despite global efforts to eradicate orthomyxoviral pathogens, these infections remain pervasive. One such orthomyxovirus, infectious salmon anemia virus (ISAV), spreads easily throughout farmed and wild salmonids, constituting a significant economic burden. ISAV entry requires the interplay of the virion-attached hemagglutinin-esterase and fusion glycoproteins. Preventing infections will rely on improved understanding of ISAV entry. Here, we present the crystal structures of ISAV hemagglutinin-esterase unbound and complexed with receptor. Several distinctive features observed in ISAV HE are not seen in any other viral glycoprotein. The structures reveal a unique mode of receptor binding that is dependent on the oligomeric assembly of hemagglutinin-esterase. Importantly, ISAV hemagglutinin-esterase receptor engagement does not initiate conformational rearrangements, suggesting a distinct viral entry mechanism. This work improves our understanding of ISAV pathogenesis and expands our knowledge on the overall diversity of viral glycoprotein-mediated entry mechanisms. Finally, it provides an atomic-resolution model of the primary neutralizing antigen critical for vaccine development.
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Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment.,Cook JD, Sultana A, Lee JE Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617993. doi:, 10.1073/pnas.1617993114. PMID:28320973<ref>PMID:28320973</ref>
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==See Also==
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*[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5t9y" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Isav]]
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[[Category: Large Structures]]
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[[Category: Cook, J D]]
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[[Category: Salmon isavirus]]
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[[Category: Lee, J E]]
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[[Category: Cook JD]]
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[[Category: Sultana, A]]
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[[Category: Lee JE]]
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[[Category: 4-0-acetylsialic acid]]
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[[Category: Sultana A]]
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[[Category: Coiled-coil]]
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[[Category: Hemagglutinin]]
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[[Category: Hydrolase]]
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[[Category: Infectious salmon anemia virus]]
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[[Category: Viral protein]]
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[[Category: Viral receptor-complex]]
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Current revision

Crystal structure of the infectious salmon anemia virus (ISAV) hemagglutinin-esterase protein

PDB ID 5t9y

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