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| - | [[Image:272d.jpg|left|200px]] | |
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| - | {{Structure
| + | ==PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE== |
| - | |PDB= 272d |SIZE=350|CAPTION= <scene name='initialview01'>272d</scene>, resolution 2.000Å
| + | <StructureSection load='272d' size='340' side='right'caption='[[272d]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>
| + | <table><tr><td colspan='2'>[[272d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=272D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=272D FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=272d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=272d OCA], [https://pdbe.org/272d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=272d RCSB], [https://www.ebi.ac.uk/pdbsum/272d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=272d ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=272d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=272d OCA], [http://www.ebi.ac.uk/pdbsum/272d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=272d RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Dautant A]] |
| - | '''PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE'''
| + | [[Category: Gallois B]] |
| - | | + | [[Category: Kennard O]] |
| - | | + | [[Category: Precigoux G]] |
| - | ==Overview==
| + | [[Category: Van Meervelt L]] |
| - | Nucleic acid triplexes are formed by sequence-specific interactions between single-stranded polynucleotides and the double helix. These triplexes are implicated in genetic recombination in vivo and have application to areas that include genome analysis and antigene therapy. Despite the importance of the triple helix, only limited high-resolution structural information is available. The x-ray crystal structure of the oligonucleotide d(GGCCAATTGG) is described; it was designed to contain the d(G middle dotGC)2 fragment and thus provide the basic repeat unit of a DNA triple helix. Parameters derived from this crystal structure have made it possible to construct models of both parallel and antiparallel triple helices.
| + | [[Category: Vlieghe D]] |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | 272D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=272D OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Parallel and antiparallel (G.GC)2 triple helix fragments in a crystal structure., Vlieghe D, Van Meervelt L, Dautant A, Gallois B, Precigoux G, Kennard O, Science. 1996 Sep 20;273(5282):1702-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8781231 8781231]
| + | |
| - | [[Category: Protein complex]] | + | |
| - | [[Category: Dautant, A.]] | + | |
| - | [[Category: Gallois, B.]] | + | |
| - | [[Category: Kennard, O.]] | + | |
| - | [[Category: Meervelt, L Van.]] | + | |
| - | [[Category: Precigoux, G.]] | + | |
| - | [[Category: Vlieghe, D.]] | + | |
| - | [[Category: b-dna]]
| + | |
| - | [[Category: double helix]]
| + | |
| - | [[Category: intermolecular base triplet]]
| + | |
| - | [[Category: overhanging base]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:47 2008''
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