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5v6e

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==Crystal structure of Myosin VI in complex with GH2 domain of GIPC1==
==Crystal structure of Myosin VI in complex with GH2 domain of GIPC1==
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<StructureSection load='5v6e' size='340' side='right' caption='[[5v6e]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
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<StructureSection load='5v6e' size='340' side='right'caption='[[5v6e]], [[Resolution|resolution]] 3.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5v6e]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V6E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5v6e]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V6E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v6b|5v6b]], [[5v6h|5v6h]], [[5v6r|5v6r]], [[5v6t|5v6t]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.506&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6e OCA], [http://pdbe.org/5v6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v6e RCSB], [http://www.ebi.ac.uk/pdbsum/5v6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v6e OCA], [https://pdbe.org/5v6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v6e RCSB], [https://www.ebi.ac.uk/pdbsum/5v6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v6e ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GIPC1_MOUSE GIPC1_MOUSE]] Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity). [[http://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
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[https://www.uniprot.org/uniprot/GIPC1_MOUSE GIPC1_MOUSE] Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5v6e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5v6e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shang, G]]
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[[Category: Large Structures]]
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[[Category: Zhang, X]]
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[[Category: Mus musculus]]
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[[Category: Helical bundle]]
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[[Category: Shang G]]
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[[Category: Protein binding]]
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[[Category: Zhang X]]

Current revision

Crystal structure of Myosin VI in complex with GH2 domain of GIPC1

PDB ID 5v6e

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